Introduction

PKPDrugs is a model-informed precision dosing (MIPD) application. It helps clinical teams turn a patient’s measured drug concentrations into an individualized dosing recommendation, using population pharmacokinetic (PK) models.

In practice, that means: record what doses a patient received and what concentrations were measured, let PKPDrugs estimate that patient’s own PK parameters (a Bayesian fit against the drug’s population model), then use that estimate to optimize future doses, simulate a proposed regimen before it’s given, and produce a PDF report to share with the care team.

Core concepts

Concept	What it means in PKPDrugs
Center	A hospital or clinical site. Every patient and every drug belongs to a center; a drug must be assigned to a center before it can be used in that center’s episodes.
Patient	A person identified by a center-scoped patient ID, birthdate, and gender.
Drug	A named PK/PD configuration — administration route, dosing unit, and a PK model file — tied to a pharmaceutical compound. Managed by administrators.
Episode	One treatment course: a single patient paired with a single drug. Everything else (doses, concentrations, covariates, estimation, optimization, simulation, reports) belongs to an episode.
Covariates	Patient factors the drug’s model uses to individualize predictions — lab values, body measurements, or extracorporeal devices (e.g. dialysis). Which covariates apply depends on the drug’s model.

Two audiences

• Clinical users work inside episodes: creating patients, opening episodes, recording doses/concentrations/covariates, and reading estimation, optimization, simulation and report results. See the User Guide.
• Administrators additionally maintain the shared catalog everyone else depends on: centers, user accounts, the covariate catalog, and drugs with their PK model files. See the Administration Guide (requires an administrator login to view).

Where to start

If you’re setting up PKPDrugs for a team for the first time, an administrator needs to create a center, add users, and add at least one drug with its PK model before clinical users can create patients and episodes. See Administration overview.

The workflow at a glance

Each step below unlocks the next — for example, you can’t add a concentration before at least one dose exists, and estimation only runs once there’s at least one dose and one concentration.

1. 1Patient
   →
2. 2Episodepatient + drug
   →
3. 3Doses
   →
4. 4Concentrations
   →
5. 5Covariates
   →
6. 6Estimationruns automatically
   →
7. 7Optimizationsteady state only
   →
8. 8Simulation
   →
9. 9Report

You can open this documentation from the application: the Documentation link at the foot of the sign-in page and of every page, and in the account menu. The Add dose form has a help link that opens the Doses page. An administrator also finds the Administration guide there. If your organization has not set up the documentation site, these links do not appear.

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